Single molecule force spectroscopy mechanically manipulates proteins
Extreme-adapted organisms from physical and chemical extremes
Highly compressed water structure observed in a perchlorate aqueous solution
We are developing experimental and computational techniques to explore the physics of living systems under extreme environmental conditions including high and low temperatures, high salt concentrations and high and low pH. Extremophiles are organisms which survive and thrive in extreme environments. The proteins from extremophilic single-celled organisms are structurally stable and functionally active under extreme physical and chemical conditions. These proteins provide excellent model systems to determine the role of non-covalent interactions in defining protein stability and dynamics as well as being attractive targets for the development of robust biomaterials.